(Prilep P-156/1 and Yaka Yv-125/3) was used. Soil cultures were grown in controlled experimental conditions, in a glasshouse of the Institute of Biology (Faculty of Natural Sciences and Mathematics-Skopje). For each treatment ten plants were taken and were treated with four concentrations of heavy metals: CuSO4 x 5H2O (0.25 mg/kg soil, 0.5 mg/kg soil, 1mg/kg soil, 5 mg/kg soil), CdSO4 x 8H20 (0.1 mg/kg soil, 0.2 mg/kg soil, 0.4 mg/kg soil and 0.8 mg/kg soil), Pb(NO3)2 (50 mg/kg soil, 100 mg/kg soil, 200 mg/kg soil, 400 mg/kg soil) and the excess concentration (unallowable for global use) of Antracol WP-70 (0.2 mg/kg soil, 0.4 mg/kg soil, 0.8 mg/kg soil and 1.6 mg/kg soil). Antracol WP-70 is fungicide of the dithiocarbamate group, with zinc as its basic constituent. In the same time, a trial with control group of ten tobacco plants was set up. Of ten fully matured leaves from lower, middle and upper leaf belts was collected for analyses. All analysis was performed in triplicate. For the aim of this paper, leaves from the upper belt (III insertion) were used. The accent was put on the analyses of chloroplast pigments content (spectrophotometric method of Holm & Wettstein, 1958) catalase activity (titrimetric method of Bach & Oparin) and anthocyanins content (spectrophotometry at 510 nm).

Key words: intoxication, tobacco, heavy metals, fungicide, chloroplast pigments